Paul Allen, who co-founded Microsoft, has died aged 65 from complications of non-Hodgkin’s lymphoma. He had revealed the disease’s return only two weeks ago, after previously being treated for it in 2009. He had said he and his doctors were “optimistic” about treatment. He was an investor, entrepreneur and philanthropist who influenced many aspects of modern life — from technology and science to sports and music.

Non-Hodgkin’s lymphoma, like the less-common Hodgkin’s disease, is a cancer of the lymphatic system. “My brother was a remarkable individual on every level,” Allen’s sister, Jody Allen, said in a statement on behalf of his family. “He was a much-loved brother and uncle, and an exceptional friend.”

Allen founded Microsoft with Bill Gates in 1975, several years after the two met as fellow students at a private school in Seattle. Allen left the company in 1982 after he was diagnosed with Hodgkin’s disease.

“I am heartbroken by the passing of one of my oldest and dearest friends, Paul Allen,” Microsoft founder Bill Gates said in a statement Monday. “Paul was a true partner and dear friend. Personal computing would not have existed without him.”

Microsoft CEO Satya Nadella called Allen’s contributions “indispensable.”

“As co-founder of Microsoft, in his own quiet and persistent way, he created magical products, experiences and institutions, and in doing so, he changed the world,” Nadella added.

Allen didn’t slow down after leaving Microsoft. He stayed on the company’s board of directors for several years while establishing his own philanthropic foundation, along with Vulcan, his investment firm.

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